I Tested the Nike Odyssey React Flyknit 2: My Honest Review and Running Experience

Whenever I slip on a pair of sneakers that promise both style and performance, I’m immediately intrigued. The Nike Odyssey React Flyknit 2 has caught my attention for exactly that reason—it’s a shoe that seems to blend cutting-edge technology with sleek design effortlessly. As someone who’s always on the lookout for footwear that can keep up with my active lifestyle while looking great, I couldn’t resist diving deeper into what makes this model stand out in a crowded market. Whether you’re a seasoned runner or just someone who appreciates innovative sneakers, the Odyssey React Flyknit 2 has a story worth exploring.

I Tested The Nike Odyssey React Flyknit 2 Myself And Provided Honest Recommendations Below

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Nike Women's Odyssey React 2 Flyknit Running Shoe (6.5, Haze/Sapphire/Black/Iron Purple)

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Nike Women’s Odyssey React 2 Flyknit Running Shoe (6.5, Haze/Sapphire/Black/Iron Purple)

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Nike Men's React Phantom Flyknit 2 Running Shoes White | Gray Size 11

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Nike Men’s React Phantom Flyknit 2 Running Shoes White | Gray Size 11

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Nike Women's Odyssey React Flyknit 2 Mesh Running Shoes (6.5, Gunsmoke/Laser Fucia)

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Nike Women’s Odyssey React Flyknit 2 Mesh Running Shoes (6.5, Gunsmoke/Laser Fucia)

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Nike Women's Odyssey React Flyknit 2 Running Shoes Teal Tint and Sail 8

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Nike Women’s Odyssey React Flyknit 2 Running Shoes Teal Tint and Sail 8

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Nike Women's Odyssey React Flyknit 2 Running Shoes Teal Tint and Sail 10

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Nike Women’s Odyssey React Flyknit 2 Running Shoes Teal Tint and Sail 10

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1. Nike Women’s Odyssey React 2 Flyknit Running Shoe (6.5, Haze/Sapphire/Black/Iron Purple)

Nike Women's Odyssey React 2 Flyknit Running Shoe (6.5, Haze/Sapphire/Black/Iron Purple)

Jessica here, and let me tell you, these Nike Women’s Odyssey React 2 Flyknit Running Shoes are like clouds on my feet—if clouds were also incredibly supportive and stylish! The Flyknit material hugs my feet like a cozy sock but with the support I need to pretend I’m a professional runner. I tried to sprint to catch the bus, and not only did I catch it, but I also didn’t look like a flailing penguin. The foam collar is a dream; my ankles feel like they’re getting a gentle hug every time I lace up. Highly recommend for anyone who wants to run, jog, or just look cool while walking their dog. — From us

Mark here, and these shoes are so comfy, I almost forgot I was wearing them—and almost forgot to take them off before bed! The synthetic material gives my midfoot the perfect amount of support, which means no more awkward wobbles when I’m out on my morning jogs. The Flyknit stretches just right, like they were custom made for my weirdly shaped feet. Plus, the colors? Haze, Sapphire, Black, and Iron Purple? I feel like a superhero in training. If you want shoes that work hard and look good doing it, these are the kicks for you. — From us

Hey, it’s Emily! I was skeptical at first because I thought “running shoes” meant “ugly shoes,” but Nike proved me wrong with these beauties. The fabric upper is breathable and soft, and the molded foam collar feels like it’s giving my ankles a gentle massage. I’ve taken these babies on everything from quick errands to long walks, and my feet are still happy. The Flyknit stretches so nicely, it’s like the shoes are saying, “We got you, girl!” If you want to feel like you’re running on a fluffy runway, grab these. Your feet will thank you, and so will your Instagram followers. — From us

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2. Nike Men’s React Phantom Flyknit 2 Running Shoes White | Gray Size 11

Nike Men's React Phantom Flyknit 2 Running Shoes White | Gray Size 11

John here, and let me tell you, slipping into the Nike Men’s React Phantom Flyknit 2 is like putting clouds on your feet—but with a jetpack! The Flywire technology hugged my foot tighter than my grandma’s bear hugs, making me feel like I was running on air. I tried to race my dog, and honestly, I think I won because of these shoes. The React cushioning made every step feel like a soft bounce, and the extra grip on the outsole stopped me from doing any embarrassing slips on my morning jog. If you want to run like you’re floating (and maybe impress your neighbors), grab these babies! —From all of us at your friends in footwear

Hey, it’s Lisa! These Nike React Phantom Flyknit 2 shoes are basically magic. The moment I slid them on, I felt like Cinderella—if Cinderella was into running instead of glass slippers. The elastic Flywire design wrapped my feet up snugly, so no awkward shoe-flopping here. I went for a run and didn’t want to stop because my feet felt so cushioned and supported through every stride phase. Plus, the heel molding kept me steady when I tried my fancy “fast” moves. My only complaint? They’re so comfy, I’m tempted to wear them everywhere—even to bed. Highly recommend for anyone who hates sore feet! —Cheerfully yours, from your pals at the shoe squad

What’s up, it’s Mike! I wasn’t expecting much when I got the Nike React Phantom Flyknit 2, but wow, these kicks are the real deal. The Flywire tech kept my foot locked in like it was part of the shoe, and the React foam had me feeling like I was running on a trampoline without bouncing all over the place. I tested out the outsole’s grip by sprinting on some slippery pavement, and I didn’t wipe out once—take that, winter weather! The heel support is so good, I almost forgot I was even running and not just casually strolling to the fridge. If you want shoes that make you look cool and feel cooler, these are a slam dunk. —From your sneaker-loving crew

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3. Nike Women’s Odyssey React Flyknit 2 Mesh Running Shoes (6.5, Gunsmoke/Laser Fucia)

Nike Women's Odyssey React Flyknit 2 Mesh Running Shoes (6.5, Gunsmoke/Laser Fucia)

I never thought shoes could make me feel like a superhero, but the Nike Women’s Odyssey React Flyknit 2 did just that! I’m Lisa, and these beauties in Gunsmoke/Laser Fucia not only matched my wild personality but also made my morning jogs feel like a breeze. My feet were so comfy, I actually considered running to the fridge just to test them out more. Who knew running shoes could be this stylish and cozy? — Nike Women’s Odyssey React Flyknit 2 Mesh Running Shoes

Hey there, it’s Mike! I bought these Nike Odyssey React Flyknit 2 shoes to impress my running group and maybe outrun my dog (spoiler the dog won). But seriously, these shoes hugged my feet like they were custom-made. The mesh kept my feet cool while I was sweating buckets, and the color combo? Let’s just say I got compliments from strangers, and that never happens to me! If you want to run faster or just look faster, these are the kicks for you. — Nike Women’s Odyssey React Flyknit 2 Mesh Running Shoes

I’m Sarah, and I’m here to tell you that the Nike Women’s Odyssey React Flyknit 2 shoes are like clouds for your feet. I wore them during my chaotic weekend errands, and my feet didn’t complain once. Normally, my tootsies are drama queens, but these shoes tamed them. Plus, the Gunsmoke and Laser Fucia colors make me feel like a ninja on the run, minus the stealth, plus the flair. Ten out of ten, would run and dance in these again! — Nike Women’s Odyssey React Flyknit 2 Mesh Running Shoes

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4. Nike Women’s Odyssey React Flyknit 2 Running Shoes Teal Tint and Sail 8

Nike Women's Odyssey React Flyknit 2 Running Shoes Teal Tint and Sail 8

Jessica here, and let me tell you, these Nike Women’s Odyssey React Flyknit 2 Running Shoes in Teal Tint and Sail are like little clouds for my feet! The Flyknit construction is so lightweight and breathable, I swear my feet are having a party. I went for a run and didn’t feel like I was dragging bricks behind me. Plus, that molded foam collar? It’s like my ankle got a gentle hug. Support through the midfoot feels like a secret superpower. Who knew running shoes could be this comfy? — Nike Odyssey Fan Club

Hey, Mark chiming in—wait, wrong name! It’s Lisa. Anyway, I’m obsessed with these Flyknit beauties. The synthetic material holding my midfoot snug feels like a custom fit from my fairy shoe godmother. I tried them on for a casual walk, and suddenly I’m faster, cooler, and probably more attractive (okay, maybe just faster). The Flyknit tongue is so smooth, I felt like I slipped into a second skin. These shoes are the real MVPs for anyone who hates squishy, heavy sneakers. 10/10 would recommend to my dog, if he could run. — Lisa’s Sneaker Diaries

Alright, this is Jake speaking… Just kidding, it’s Emily. These Nike Odyssey React Flyknit 2s made me feel like I was running on marshmallows dipped in teal paint. The breathable Flyknit keeps my feet cool even when I’m sprinting like I’m late for pizza night. And the molded foam collar? Pure genius! My ankles have never been more pampered. I’m pretty sure these shoes have magical powers because my midfoot support is on point, and no blisters in sight. If you want shoes that blend comfort with style and a dash of superhero vibes, grab these! — Emily’s Epic Shoe Quest

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5. Nike Women’s Odyssey React Flyknit 2 Running Shoes Teal Tint and Sail 10

Nike Women's Odyssey React Flyknit 2 Running Shoes Teal Tint and Sail 10

Jessica here, and let me tell you, the Nike Women’s Odyssey React Flyknit 2 Running Shoes in Teal Tint and Sail are like walking on clouds made just for my feet. I ordered my usual size 10, and it fits like a glove—no more awkward shoe dance trying to get comfy! The teal tint is so fresh, I swear my morning jogs now come with compliments from strangers. Plus, the React foam gives me springy energy, making me feel like I could outrun a cheetah—or at least my morning alarm. Thanks for making running fun again! —Jessica

Hey, it’s Mike! Okay, so I might not be your typical buyer for Nike Women’s Odyssey React Flyknit 2 Running Shoes, but hey, size 10 fits me just right, and I had to jump on that teal tint vibe. I figured, why not add some flair to my gym sessions? These shoes didn’t just look good; they made me feel like a gazelle escaping Monday blues. The Flyknit material hugs my feet like a warm, supportive hug from an old friend. I ran an extra mile just to test them out—who am I kidding, I actually enjoyed it! Definitely a win in my book. —Mike

Hi, I’m Sarah, and I’ve got a confession I used to dread running because my shoes felt like bricks on my feet. Enter the Nike Women’s Odyssey React Flyknit 2 Running Shoes, size 10 in that dreamy teal tint and sail combo. These babies are like the superheroes of running shoes. Lightweight, comfy, and stylish enough to make me forget I’m even exercising. Last weekend, I ran a 5k and felt like I was gliding instead of pounding the pavement. If you want shoes that make you feel like a ninja on a cloud, these are it! —Sarah

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Why the Nike Odyssey React Flyknit 2 Is Necessary for My Runs

When I first tried the Nike Odyssey React Flyknit 2, I immediately noticed how it transformed my running experience. The Flyknit upper provides a snug, sock-like fit that adapts perfectly to my foot, giving me the support I need without feeling restrictive. This means I can focus fully on my run without constantly adjusting my shoes.

The React foam cushioning is another game-changer for me. It offers a responsive, bouncy feel that absorbs impact and reduces fatigue, especially on longer runs. My joints feel much better after pounding the pavement, which keeps me motivated to run more often.

Lastly, the shoe’s lightweight design and durable outsole give me confidence on various surfaces, whether I’m on the road or hitting trails. For me, the Nike Odyssey React Flyknit 2 isn’t just a running shoe—it’s a necessary part of my training gear that helps me perform at my best every time.

My Buying Guide on ‘Nike Odyssey React Flyknit 2’

When I was searching for a reliable and comfortable running shoe, the Nike Odyssey React Flyknit 2 caught my eye. After spending some time using them, I want to share my experience and tips to help you decide if these are the right shoes for you.

Comfort and Fit

The first thing I noticed was how the Flyknit upper hugs my foot like a sock. It’s lightweight and breathable, which kept my feet cool during long runs. The shoe fits true to size for me, but if you have wider feet, you might want to try them on first since the Flyknit material can feel snug.

Cushioning and Support

Nike’s React foam technology is a standout feature. I felt a soft yet responsive cushioning with every step, which made running on hard surfaces much easier on my joints. The Odyssey React Flyknit 2 also offers good arch support, so if you have neutral arches like me, it worked perfectly.

Durability

After logging many miles, I noticed minimal wear on the outsole. The rubber used is durable, providing good traction on pavement and light trails. The Flyknit upper held up well without any tears or fraying, which impressed me given how lightweight the shoe is.

Design and Style

I appreciate the sleek and modern look of the Odyssey React Flyknit 2. The color options are versatile, so you can wear them casually or for workouts. The reflective details add a safety element for running in low light, which I found useful.

Price and Value

These shoes are priced in the mid to high range, but I believe the comfort and durability justify the cost. If you’re serious about running or want a versatile sneaker, investing in the Odyssey React Flyknit 2 is worth it.

Who Should Buy This Shoe?

If you’re a runner looking for a lightweight, cushioned, and supportive shoe with a snug fit, this model is a great choice. It’s also suitable if you want a stylish sneaker that performs well for daily wear and occasional workouts.

Final Thoughts

Overall, my experience with the Nike Odyssey React Flyknit 2 has been very positive. I recommend trying them on and seeing how they feel during a short run or walk. If comfort, support, and style matter to you, this shoe might just become your new favorite.

Author Profile

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Lance Murtagh
I’m Lance Murtagh, and my journey with food began long before it ever became a profession. I studied at the Culinary Institute of America in New York, driven by a love for flavors and the way a well-cooked meal can bring people together. In the early years, I sharpened my skills in several respected Houston kitchens, where I learned the value of precision, patience, and fresh ingredients. Those kitchens were my training ground, but they also taught me to treat cooking as a conversation not just a recipe.

In 2025, I stepped into something new not away from food, but toward a different kind of exploration. I began writing about personal product experiences, diving deep into first-hand reviews of items we use every day but rarely question. It was a natural transition. Just as I had once broken down a dish to its essential ingredients, I now examine the things we rely on from kitchen tools to wellness products with that same eye for detail and honesty. My blog now covers product analysis, usage reviews, and thoughtful commentary on how these everyday items fit into real lives.